bone marrow necrosis: frequency and clinicopathilogical findings in marrow biopsyes

نویسندگان

ezat rahimi

ali eishi

behrooz ilkhanizade

چکیده

background and objectives: bone marrow necrosis (bmn) is a rare and ominous complication of wide variety of diseases including hematologic malignancy. this study was performed to identify frequency and the underlying associated diseases of marrow necrosis. materials and methods: in this descriptive study, totally 850 bone marrow trephine biopsies related to living patients at the pathology department of urmia imam hospital from march 1998 to january 2008, were retrospectively reviewed. the reviews included clinical and laboratory findings from files of the patients. results: eight cases of bone marrow necrosis were found. frequency was 0.94 percent. ages of the patients were between 18 and 85 years, and four of them were female. prominent symptoms of the patients were bone pain, fever, fatigue, and jaundice. the most common laboratory findings were anemia, cytopenia, elevated lactate dehydrogenase (ldh), and alkaline phosphatase (alp). underlying diseases of bone marrow necrosis in our patients includes systemic lupus erythematosus, multiple myeloma, metastatic gastric cancer, acute myeloid leukemia (m4), hairy cell leukemia, lymphoma, chronic myeloid leukemia and sepsis. conclusion: our findings suggest that the conditions associated with bmn are varied and malignancy remains common. in cases presented with pyrexia, bone pain, pancytopenia, elevated ldh and alk, marrow necrosis must be thought. although prognosis is very bad, supplementary therapy, in addition to the underlying disease must be performed.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Bone Marrow Necrosis: Frequency and clinicopathilogical Findings in Marrow Biopsyes

  Background and Objectives: Bone marrow necrosis (BMN) is a rare and ominous complication of wide variety of diseases including hematologic malignancy. This study was performed to identify frequency and the underlying associated diseases of marrow necrosis. Materials and Methods: In this descriptive study, totally 850 bone marrow trephine biopsies related to living patients at the Pathology ...

متن کامل

The Role of Bone Marrow Aspiration and Bone Marrow Biopsy in Diagnosis of Bone Marrow Metastases

Background: Bone marrow is the site of many malignant disorders and it is one of the common places for solid tumors to metastasize. Examination of the bone marrow aspirate and biopsy is a routine procedure performed for assessment of various conditions such as cytopenias, hematologic neoplasms, nonmalignant disorders and metastatic neoplasms. Methods: The patients were referred to the Hema...

متن کامل

Bone Marrow and Karyotype Findings of Patients with Pancytopenia in Southern Iran

Background: Pancytopenia is a manifestation of a wide range of disorders. The main prognostic factor for predicting outcome and response to treatment is based on the underlying cause. To detect the root cause of this problem, depending on other accompanied signs or symptoms, the need for bone marrow examination and other advanced work ups is different at least at the practical level. This study...

متن کامل

Nurse and Bone Marrow Transplant

پیوند مغز استخوان باید به مدت طولانی در بیمارستان بستری باشند، که این امر نیز موجب بروز برخی از عوارض روانی مانند: افسردگی، اضطراب، کج خلقی، ترس و ناامیدی در آنان خواهد شد. هرچند که برخورد صحیح کادر مراقبتی درمانی می تواند تا حد زیادی از این عوارض پیشگیری کند. در این مسیر تقویت اعتماد، اعتقاد، امید و تلاش برای سازگاری با مشکل ضرورت دارد. امروزه بسیاری از بیماریهای بدخیم به درمان با پیوند مغز اس...

متن کامل

Difference in the Cytomegalovirus-related clinical laboratory findings between patients with bone marrow and kidney transplantation

Background: Despite close monitoring of transplant patients, cytomegalovirus (CMV) infection remains one of the most critical problems in the field of transplantation. This study aims to investigate the relationship between CMV viral load and clinical laboratory findings in transplant recipients. Materials And Methods: Thirty-four transplant recipients comprising 15 kidney transplant (KT) reci...

متن کامل

Bone marrow necrosis in acute lymphoblastic leukemia.

Bone marrow necrosis, an uncommon finding in acute lymphoblastic leukaemia, has previously been regarded as a poor prognostic feature. It has been associated with difficulty in establishing the diagnosis, a low rate of remission as well as short remission duration. We report a case of bone marrow necrosis in a girl with acute lymphoblastic leukaemia and good prognostic features who attained com...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید


عنوان ژورنال:
iranian journal of pathology

ناشر: iranian society of pathology

ISSN 1735-5303

دوره 4

شماره 1 2009

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023